More than 2,800 flights have been cancelled Monday as .
Of the more than 2,800 cancelled flights, around 1,000 were within, into or out of the United States, according to FlightAware. Almost 11,000 flights are delayed.
Globally, airlines , Christmas and the day after Christmas. In the United States, more than 1,200 flights were cancelled and more than 5,000 were delayed on Sunday alone as staff and crew call out sick.
The cancellations come at the busiest time of year for air travel. The US Transportation Security Administration said it screened millions of people each day over the holiday weekend, peaking at 2.19 million travelers on Thursday, December 23. On Wednesday, more people passed through TSA checkpoints than on the same day in 2019.
Alaska Airlines, which cancelled 133 flights of 19% of its operations Monday, attributed its cancellations and delays on winter weather in the Pacific Northwest. The airline said it cancelled almost 250 mainline flights scheduled to arrive or depart from Seattle Sunday. As of Monday afternoon, Seattle-Tacoma International Airport has the most delays and cancellations in the world, according to FlightAware.
"We're working as quickly as possible to get all our affected guests rebooked on other flights, while operating safely," Alaska Airlines said in a statement. "Reservations is experiencing extremely long hold times of up to 11 hours."
Saturday air travel was a bit slower because of the flight cancellations: More than 1.53 million people passed through security checkpoints Saturday.
United Airlines said last week it had to cancel hundreds of flights because it lacked enough crew members to safely fly all of its scheduled routes.
"The nationwide spike in Omicron cases this week has had a direct impact on our flight crews and the people who run our operation," said a United memo obtained by CNN.
Delta said it was working to get all stranded travelers home as quickly as possible.
"We apologize to our customers for the delay in their holiday travel plans," Delta said in a statement. "Delta people are working hard to get them to where they need to be as quickly and as safely as possible on the next available flight."
European airlines are also experiencing a small number of cancellations amid record-breaking numbers of COVID-19 cases in several European nations.
A British Airways spokesperson told CNN on Monday that the airline had cancelled "a number of flights due to operational constraints," ​and are instead using larger aircrafts, where possible, to get customers to their destinations. According to tracking website FlightAware, 46 flights from British Airways were cancelled on Monday.
Virgin Atlantic told CNN flying continues "as scheduled," noting the exception of one of their London Heathrow -- New York JFK rotations which saw cancellations on December 21. A Virgin Atlantic spokesperson told CNN: "We continue to take pre-emptive measures to uphold operational and staffing resilience, always putting the health and safety of our customers and people first."
German airline Lufthansa said it will cancel 10% of its winter flight schedule as the pandemic continues to hit the aviation industry.
In an interview with Frankfurter Allgemeine Sonntagszeitung last week, Lufthansa CEO Carsten Spohr said that due to "a sharp drop in bookings" the airline will have to cancel 33,000 flights from mid-January to February 2022 or 10% of the group's winter flight schedule.
Spohr's comments were confirmed to CNN by the Lufthansa press office.
-- CNN's Pete Muntean, Arnaud Siad and Ramishah Maruf contributed to this report
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