TORONTO -- Pfizer expects Canada will be able to extract six doses of its COVID-19 vaccine from vials instead of five, a difference that has caused confusion among provinces and prompted speculation about Canada鈥檚 rollout timeline.

Health Canada is reviewing a formal request to change the label on the Pfizer BioNTech vaccines to reflect a sixth dose and is looking into whether Canada will be able to make the precise extractions.

The problem comes down to a limited supply of special syringes needed to more easily extract the sixth dose. Canada has only so many 1-millilitre, or 1cc, syringes, which are in high demand globally. Two million syringes of a recent order for 37.5 million are due to arrive in Canada on Feb. 4.

Health officials have repeatedly said that they believe Pfizer will meet its March deadline to deliver four million vaccines to Canada. However, on Thursday, officials acknowledged that Pfizer made those calculations based on the assumption that each vial had six doses, not five.

Maj.-Gen. Dany Fortin, who is overseeing Canada鈥檚 vaccine rollout, said Pfizer will increase the number of vials it sends to meet the March deadline in the event that Canada doesn鈥檛 agree to change the labels.

鈥淭hey have assured us four million by the end of March,鈥 Fortin said at a press conference on Thursday.

But a planning document sent to the provinces on Thursday morning still used the five-dose formula, which led some to believe that they could miss out on up to 500,000 doses in the coming months.

鈥淲hat we have shared with provinces is a conservative figure of five doses per vial until it changes, until authorized 鈥 if it gets authorized,鈥 Fortin said.

Provinces expressed their frustration with the situation, with Alberta鈥檚 health minister accusing the government of 鈥渇ailing Canadians鈥 and Saskatchewan Premier Scott Moe blaming Ottawa of not sharing 鈥渁ccurate information.鈥

Ontario Premier Doug Ford also expressed his disappointment with Pfzier, but did not lay blame on the federal government.

鈥淧fizer has let us down tremendously. It's, again, unacceptable,鈥 Ford said. 鈥淚 know the federal government is trying and they're doing everything we can. We need to explore every avenue possible."

Retired Gen. Rick Hillier, who is in charge of Ontario鈥檚 vaccine rollout, acknowledged how challenging it can be to extract a sixth vaccine from a vial, saying it鈥檚 become 鈥渁lmost a competition鈥 for those administering the vaccines.

鈥淭hey succeed sometimes. In some batches up to 80 per cent of the time. In some batches, not at all,鈥 Hillier said.

Pharmacists and health care workers on the frontlines have known about the possibility of getting a sixth dose for a while, and having a 1-millilitre syringe makes all the difference, Hillier said 鈥 but they鈥檙e far from guaranteed.

鈥淓very time we get (a sixth dose) it鈥檚 a win, it鈥檚 a victory, and allows us to put another needle into another arm,鈥 Hillier said.

When it comes to adjusting vaccine labels to officially add a sixth dose, CTV Infectious Disease Specialist Dr. Abdu Sharkawy said Canada needs to be careful not to give in to pressure from Pfizer.

鈥淭he reality is it is difficult to administer these vaccines with the finest of precision and it really comes down to something called dead volume,鈥 Sharkawy told CTV鈥檚 Power Play.

If someone is using a larger 3-millilitre, or 3cc, syringe 鈥 which is far more common in Canada 鈥 Sharkawy said it requires a level of skill to extract the sixth dose.

鈥淚 think it鈥檚 just too problematic to suggest that a) we鈥檙e going to be able to procure enough of these 1cc syringes that are now a hot commodity, and to be able to ensure that we鈥檙e able to extract that extra dose with the existing conventional syringes that we have right now,鈥 he said.

Because of those problems, Sharkawy said he鈥檇 be surprised if Health Canada approved the label change to include a sixth dose.

鈥淚 think we have to stand our ground and ensure that there is no vaccine wastage and that there鈥檚 no more confusion going forward.鈥

Doctors in the U.S. were the first in the world to realize that six doses could be taken from each vial if they used 1-millilitre鈥 syringes, although they are less common than the three- and five-millilitre syringes mostly used in Canada's vaccine campaign now.

Liberal MP Steve MacKinnon, who serves as parliamentary secretary to the minister of public services and procurement, denied any 鈥渂lame game鈥 going on between Ottawa and the provinces. Instead, he said Canada finds itself in a global race for vaccines at a time when Pfizer is experiencing a temporary production delay due to adjustments at its factory in Belgium.

鈥淓very single day we are communicating with the provinces, we鈥檙e supplying them with the best available data. But we are also saying this is a very dynamic situation,鈥 MacKinnon told CTV鈥檚 Power Play.

This comes as Canada is expected to receive zero new vaccine shipments this week and reduced supply in the weeks that follow. Federal officials continue to assert that Canada remains on track to have enough vaccines for every Canadian by the end of September.

But projects that Canada won鈥檛 see widespread vaccinations until mid-2022, several months after the U.S. and European Union. Instead, the report suggests, Canada鈥檚 completed vaccine rollout will be more in line with countries such as Australia and Japan.

With files from The Canadian Press