After a 12-year romance, six children and a two-year marriage, two of Hollywood鈥檚 biggest stars are splitting up. Angelina Jolie filed for divorce from Brad Pitt on Tuesday, citing irreconcilable differences.

The news was first reported by TMZ, which . Jolie is reportedly asking for physical custody of their six children.

Jolie鈥檚 attorney Robert Offer, said in a statement that his client is asking for privacy.

鈥淭his decision was made for the health of the family,鈥 Offer said. 鈥淪he will not be commenting, and asks that the family be given its privacy at this time.鈥

In a brief statement to People Magazine, Pitt said he was 鈥渟addened by this, but what matters most now is the wellbeing of our kids.鈥 He also asked for privacy for his children, 鈥渢o give them the space they deserve during this challenging time.鈥

Jolie and Pitt began and ended their relationship in the public eye. Both were already established actors when they first met on the set of the 2005 action movie Mr. and Mrs. Smith, playing husband-and-wife assassins. Pitt was married to actress Jennifer Aniston at the time. They divorced in 2005. Jolie was previously married to actors Jonny Lee Miller and Billy Bob Thornton.

Jolie and Pitt have three adopted children and three biological children: Maddox, Pax, Zahara, Shiloh, as well as Knox and Vivienne, who are twins.

After years as a couple, they were married at their estate in Provence, France in 2014.

In 鈥淏y the Sea,鈥 the 2015 film directed by Jolie, the pair play a couple vacationing together while their marriage is crumbling.

Beyond filmmaking, the pair has each devoted time to charity work and humanitarian causes. Jolie is currently a goodwill ambassador for the United Nations.

Jolie has also spoken out on women鈥檚 health issues after undergoing a double mastectomy, and later, having her ovaries and fallopian tubes removed in the hopes of reducing her risk of cancer.

Film expert and 麻豆影视 contributor Richard Crouse said, given Jolie and Pitt鈥檚 star power, their divorce won鈥檛 be easy.

鈥淭here鈥檚 a lot of money involved,鈥 Crouse told 麻豆影视 Channel. 鈥淭hey鈥檙e both such public figures, they鈥檙e two of the most famous people on the planet, so this isn鈥檛 going to be easy.鈥

Crouse also said that there is a personal cost to their split. 鈥淭hey have six kids together. It鈥檚 easy just to write it off as another Hollywood divorce and another Hollywood marriage that didn鈥檛 work out.

鈥淚t鈥檚 just a shame that there are six kids here that are going to be caught in the crossfire.鈥